Finding Genes for Uterine Fibroids
It is widely recognized that uterine leiomyomata (UL)
pose a major public health problem for women of reproductive age. These
benign tumors cause medically and socially significant symptoms including
abnormal bleeding, pelvic discomfort, and reproductive dysfunction and
are the most common cause of hysterectomy in the U.S. Despite their
major public health impact, the causes of fibroids are unknown. Recent
cytogenetic, molecular, and epidemilogic evidence suggest that there
is a stong genetic component to fibroid development. Currently, 500
sister pairs with fibroids and their families are being recruited to
complete a survey and submit a blood sample to identify genes that predispose
women to developing fibroids. More information about about this genome-wide
screen is available at the Center for Uterine Fibroids. Ultimately,
understanding the genes involved in fibroid pathogenesis may lead to
less invasive treatment options for women.
Faculty Who Conduct Research in this Area
Carolien Panhuysen, M.D., Ph.D.
Further Information
www.fibroids.net
