Diego F. Wyszynski, MD, MHS, PHD

DIEGO F. WYSZYNSKI, M.D., M.H.S, PH.D.
Associate Professor of Medicine and of Epidemiology

Education
1996, Ph.D., Johns Hopkins University School of Hygiene and Public Health
1994, M.H.S., Johns Hopkins University School of Hygiene and Public Health
1991, M.D., University of Buenos Aires School of Medicine

Contact
email: dfw@bu.edu
phone: (617) 638-5361
fax: (617) 638-4275

Research Interests

Dr. Wyszynski's research interests focus on in implementing analytic methods, such as analysis of familial correlations, segregation analysis, and linkage analysis, to elucidate the etiology of familial clustering of quantitative and qualitative traits. Specific areas of interest include birth defects (especially nonsyndromic cleft lip with/without cleft palate and neural tube defects), lipid disorders (such as the metabolic syndrome), and sickle cell disease. Dr. Wyszynski is the senior epidemiologist of the AntiEpileptic Drug (AED) Pregnancy Registry at the Massachusetts General Hospital and of the Boston University School of Medicine's Center of Excellence in Sickle Cell Disease and New England Centenarian Study. He is also an epidemiologist for the CDC-sponsored National Birth Defects Prevention Study and the NIA-sponsored Long Life Family Study.

Selected Publications since 2004

Holmes LB, Wyszynski DF , Lieberman E, for the AED Pregnancy Registry. The AED (Antiepileptic Drug Pregnancy Registry): A 6 Year Experience. Archives of Neurology 2004;61:673-678.

Wyszynski DF, Nolan V. Feasibility of identifying families for genetic studies of birth defects using the National Health Interview Survey. BMC Public Health 2004; 4:16 .

Wyszynski DF , Baldwin CT, Cleves MA, Amirault Y, Nolan VG, Farrell JJ, Bisbee A, Kutlar A, Farrer LA, Steinberg MH. Polymorphisms near a chromosome 6q QTL area are associated with modulation of fetal hemoglobin levels in sickle cell anemia. Cell Mol Biol (Noisy-le-grand) 2004;50:23-33.

Gaspar DA, Matioli SR, de Cassia Pavanello R, Araujo BC, Alonso N, Wyszynski D, Passos-Bueno MR. Maternal MTHFR interacts with the offspring's BCL3 genotypes, but not with TGFA, in increasing risk to nonsyndromic cleft lip with or without cleft palate. Eur J Hum Genet 2004;12:521-526.

Marazita ML, Murray JC, Lidral AC, Arcos-Burgos M, Cooper ME, Goldstein T, Maher BS, Daack-Hirsch S, Schultz R, Field LL, Liu Y, Prescott N, Winter R, Ray A, Moreno L, Valencia C, Neiswanger K, Wyszynski DF, Bailey-Wilson J, Albacha-Hejazi H, Beaty TH, McIntosh I, Hetmanski JB, Tunçbilek G, Edwards M, Harkin L, Scott R, Roddick LG. Meta-analysis of 13 Genome Scans Reveals Multiple Cleft Lip/Palate Genes Including a Novel Locus on 9q. American Journal of Human Genetics 2004;75:161–173.

Holmes LB, Wyszynski DF. North American Antiepileptic Drug Pregnancy Registry. Epilepsia 2004;45:1465.

Wyszynski DF , Waterworth DM, Barter PJ, Cohen J, Kesaniemi YA, Mahley RW, McPherson R, Waeber G, Bersot TP, Sharma SS, Nolan V, Middleton LT, Sundseth SS, Farrer LA, Mooser V, Grundy SM. Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project). Am J Cardiol 2005;95:194-198.

Wyszynski DF. Book review: Statistical Methods in Genetic Epidemiology by Duncan C. Thomas, Oxford University Press. American Journal of Human Genetics 2005;76:190.

Nolan VG, Baldwin C, Ma Q, Wyszynski DF, Amirault Y, Farrell JJ, Bisbee A, Embury SH, Farrer LA, Steinberg MH. Association of single nucleotide polymorphisms in klotho with priapism in sickle cell anaemia. Br J Haematol 2005;128:266-272.

Wyszynski DF, Nambisan M, Surve T, Alsdorf RM, Reilly C, Holmes LB for the AED Pregnancy Registry. Increased rate of major malformations in offspring exposed to Valproate during pregnancy. Neurology 2005;64:961-965.

Mansilla MA, Kimani J, Mitchell LE, Christensen K, Boomsma DI, Daack-Hirsch S, Nepomucena B, Wyszynski DF, Felix TM, Martin NG, Murray JC. Discordant MZ twins with cleft lip and palate: a model for identifying genes in complex traits. Twin Research and Human Genetics 2005; 8:39 -46.

Alsdorf R, Wyszynski DF. Teratogenicity of sodium valproate. Expert Opinion on Drug Safety 2005;4:345-353.

Bañares VG, Peterson G, Aguilar D, Gulayin R, Sisu E, Wyszynski DF, Pivetta OH, Tavella MJ. The association between the APOE*4 allele and atherosclerosis is age-dependent among Argentine males. Human Biology 2005;77:247-256.

Wyszynski DF, Perandones C, Bennun RD. Family Environment of Individuals with Oral Clefts in Argentina . Cleft Palate Craniofac J 2005;42:185-191.

Wyszynski DF, Sárközi A, Czeizel AE. Oral clefts with associated anomalies: methodological issues. Cleft Palate-Craniofacial Journal 2005;In Press.

Baldwin C, Nolan VG, Wyszynski DF, Ma QL, Sebastiani P, Embury SH, Bisbee A, Farrell J, Farrer L, Steinberg MH. Association of Klotho, bone morphogenic protein 6 and annexin A2 polymorphisms with sickle cell osteonecrosis. Blood. 2005 Published online Mar ch 22.

Nolan VG, Wyszynski DF, Baldwin C, Farrell JJ, Bisbee A, Farrer LA, Steinberg MH. Hemolysis associated priapism in Sickle Cell Disease. Blood. 2006 (In Press)

Books

Wyszynski DF (editor). Cleft Lip and Palate: From Origin to Treatment. Oxford University Press, New York, 2002.

Wyszynski DF (editor). Neural Tube Defects: From Origin to Treatment. Oxford University Press, New York, 2005

		HOME \| SEARCH