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Mark W. Logue, PH.D.
Research Assistant Professor, Dept of Medicine (Genetics Program), BUSM

Education
2001-2002 NIMH Post-Doctoral Research Fellow, Psychiatry, University of Iowa, Iowa City IA.
2001 - PhD Statistics - University of Iowa, Iowa City IA.
1996 - MS in Statistics - University of Iowa, Iowa City IA.
1994 - BS in Mathematics - University of Oregon, Eugene OR.
Research Interests

Linkage analysis correlates genetic information with disease status in families to localize genes with disease causing variants. Dr. Logue’s research involves developing and evaluating strategies for dealing with an unknown genetic model in linkage analysis. Most of this has occurred within the framework of a Bayesian statistic called the posterior probability of linkage, or PPL. The PPL allows for the direct incorporation of an unknown genetic model in linkage analysis, while retaining the ability to utilize large pedigrees. It has been shown to be an effective tool in simulations, and has been used to look for genes for panic disorder, language impairment, schizophrenia, autism, and cleft lip- palate. Dr. Logue is currently undertaking an NIMH funded training program which allow him to specialize in the genetics of psychiatric disease while attempting to localize panic disorder genes in a large multi-site sample of families.
Selected Publications

Logue MW, Brzustowicz LM, Bassett AS, Chow EWC, Vieland VJ. 2006. A Posterior Probability of Linkage-Based Re-Analysis of Schizophrenia Data Yields Evidence of LInkage to Chromosomes 1 and 17. Human Heredity 62: 47-54.

Logue MW, Vieland VJ. 2005. The incorporation of prior genomic information does not necessarily improve the performance of Bayesian linkage methods: An example involving sex-specific recombination and the two-point PPL. Human Heredity 60: 196-205.

Park, JW, Logue M, Ni J, J Cremer, Segre A, Vieland V, 2005. Scientific Visualization of Multidimensional Data: Genetic Likelihood Visualization, Current Trends in High Performance Computing and Its Applications, Proceedings of the International Conference on High Performance Computing and Applications, August 8-10, 2004, Shanghai, P.R. China, Zhang, W.; Chen, Z.; Glowinski, R.; Tong, W. (Eds.). pp. 403-408.

Yang X, Huang J, Logue MW, Vieland VJ. 2005. The Posterior Probability of Linkage Allowing for Linkage Disequilibrium and a New Estimate of Disequilibrium between a Trait and a Marker. Human Heredity 59:210-219.

Logue MW, Vieland VJ. 2004. A New Method for Computing the Multipoint Posterior Probability of Linkage. Human Heredity 57: 90-99.

Bartlett CW, Flax JF, Logue, MW, Smith BJ, Vieland VJ, Tallal P, and Brzustowicz LM. 2004 Examination of Potential Overlap in Autism and Language Loci on Chromosomes 2, 7, and 13 in Two Independent Samples Ascertained for Specific Language Impairment. Human Heredity 57:10-20.

Logue MW, Vieland VJ, Goedken RJ, and Crowe RR. 2003. Bayesian Analysis of a Previously Published Genome Screen for Panic Disorder Reveals New and Compelling Evidence for Linkage to Chromosome 7. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 121B:95-99.

Bartlett, CW, Flax JF, Logue MW, Vieland VJ, Bassett AS, Tallal P, and Brzustowicz LM. 2002 A Major Susceptibility Locus for Specific Language Impairment is located on 13q21 American Journal of Human Genetics 71: 45-55.

Vieland VJ, Logue, M. 2002. HLODs, trait models, and ascertainment: Implications of admixture for parameter estimation and linkage detection, Human Heredity 53: 23-35.

Wang K, Huang J, Logue M, and Vieland VJ. 2001. Combined multipoint analysis of multiple asthma data sets based on the posterior probability of linkage, In: Wijsman EM, Almasy L, Amos CI, Borecki I, Falk CT, King TM, Martinez MM, Meyers D, Neuman R, Olson JM, Rich S, Spence MA, Thomas DC, Vieland VJ, Witte JS, MacCluer JW. Analysis of complex genetic traits: Applications to asthma and simulated data. Genetic Epidemiology, 21 (Suppl. 1): S73-S78.
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