Clinton T. Baldwin, Ph.D.

CLINTON T. BALDWIN, PH.D.
Professor of Pediatric Medicine

Education
1986 Ph.D., Biochemistry, Boston University
1980 M.S., Microbiology, Northeastern University
1977 B.S. Biology, University of Connecticut

Research Interests

Broadly speaking, the goal of the research I conduct is the identification of genes that cause diseases in humans. Current techniques for isolating disease genes involve the use of statistical methods on pedigrees of related affected and unaffected individuals. These methods are often computationaly intensive since the scale of the human genome is so large and even a small representation of the 3 billion or so bases that comprise an individuals genetic identity can be insufficient. It is thus one of the goals of the lab to try to utilize the computational facilities available at Boston University to provide a solution for this problem both in terms of increasing the accuracy of results and decreasing the time needed to produce them.

Selected Publications

Baldwin CT, Hoth C, Amos J, da Silva E, Milunsky A. An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome. Nature. 1992 Feb 13;355(6361):637-8.

Baldwin C, Lipsky N, Hoth C, Mamuya W, Milunsky A. Mutations in PAX3 associated with Waardenburg syndrome type I. Hum Mutat. 1994;3(3):205-11.

Baldwin C, Farrer L, Adair R, Dharmavaram R, Jimenez S, Anderson L. Linkage of early-onset osteoarthritis and chondrocalcinosis to human chromosome 8q. Am J Hum Genet. 1995 Mar;56(3):692-7.
Baldwin C, Hoth C, Macina R, Milunsky A. Mutations in PAX3 that cause Waardenburg syndrome type I: ten new mutations and review of the literature. Am J Med Genet. 1995 Aug 28;58(2):115-22. Review.

Baldwin C, Bonne-Tamir B, Weiss S, DeStefano A, Adair R, Franklyn B, Kidd K, Korostishevsky M, Farrer L. Linkage of congenital, recessive deafness (DFNB4) to chromosome 7q31 and evidence for genetic heterogeneity in the Middle Eastern Druze population. Hum Mol Genet. 1995 Sep;4(9):1637-42.

Bonne-Tamir B, DeStefano A, Briggs C, Adair R, Franklyn B, Weiss S, Korostishevsky M, Frydman M, Baldwin C, Farrer L. Linkage of congenital recessive deafness (gene DFNB10) to chromosome 21q22.3. Am J Hum Genet. 1996 Jun;58(6):1254-9.

Baima J, Nicolaou M, Schwartz F, DeStefano A, Bursztyn M, Handy D, Manolis A, Gavras I, Farrer L, Baldwin C, Gavras H. Evidence for linkage between essential hypertension and a putative locus on human chromosome 17. Hypertension. 1999 Jul;34(1):4-7.

Baldwin C, Cupples LA, Joost O, Demissie S, Chaisson C, McAlindon T, Myers R, Felson D. Absence of linkage or association for osteoarthritis with the vitamin D receptor/type II collagen locus: the Framingham Osteoarthritis Study. J Rheumatol. 2002 Jan;29(1):161-5.

DeStefano AL, Gates GA, Heard-Costa N, Myers RH, Baldwin C. Genomewide linkage analysis to presbycusis in the Framingham Heart Study. Arch Otolaryngol Head Neck Surg. 2003 Mar;129(3):285-9.

Farrer LA, Bowirrat A, Friedland RP, Waraska K, Korczyn AD, Baldwin C. Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community. Hum Mol Genet. 2003 Feb 15;12(4):415-22.

Erlich PM, Cui J, Chazaro I, Farrer LA, Baldwin C, Gavras H, DeStefano AL. Genetic variants of WNK4 in Whites and African Americans With hypertension. Hypertension. 2003 Jun;41(6):1191-5. Epub 2003 Apr 28.

		HOME \| SEARCH