Genetics of Epidemiology
and Disease - Fall 2004
Wednesdays, 10:00 - 12:00 noon, Room L320
Course Director - Dr.
Lindsay Farrer
Faculty: Drs. Kenn Albrecht, Clint Baldwin, Lindsay Farrer, Carolien Panhuysen,
Marsha Wilcox, Diego Wyszynski
Primary Textbook: Strachan, T. & Read R. Human Molecular
Genetics, 3rd Edition. Garland Science / Taylor & Francis Group, October
2003.
NOTE ON REFERENCES: Required or strongly recommended
readings are marked with an asterisk (*). The other readings are recommend
for addtional background in the subject area and supplement the required
readings. Other readings may be recommended upon request from the instructor.
Syllabus (abridged)
Download full version
| September 8 |
Lecture 1: Introduction
(Dr. Farrer) |
*1. Human
Molecular Genetics. Ch. 4, pp. 102-110.
*2. Jorde, Carey, Bamshad & White. Medical Genetics, 3rd Edition.
Mosby, 2003. Ch 1 (handout)
|
| September 15 |
Lecture 2: Genetics Tools and Genomics
(Dr. Baldwin) |
*2. www.ncbi.ncm.nih.gov |
| September 22 |
Lecture 3: Chromosomes and Chromosome
Abnormalities (Dr. Thiagalingam) |
*1. Human Molecular Genetics, Ch. 2,
pp. 35-38
*2. Human Molecular Genetics, Ch. 4, pp. 104
*3. Human Molecular Genetics, Ch. 10, pp. 301-306 |
| September 29 |
Lecture 4: Cancer Genetics (Dr. Thiagalingam) |
*1. Human Molecular Genetics, Ch. 17,
pp. 487-507
2. Thiagalingam S, Foy RL, Cheng K-H, Lee HJ, Thiagalingam A, Ponte
JF. Loss of heterozygosity as a predictor to map tumor suppressor
genes in cancer: molecular basis of its occurrence. Curr Opin Oncol.
2002 Jan;14(1):65-72. Review. Erratum in: Curr Opin Oncol 2002 May;14(3):374.
3. Cairns P, Sidransky D. Molecular methods for the diagnosis of cancer.
Biochim Biophys Acta. 1999 Mar 25;1423(2):C11-8.
4. Fahraeus R, Fischer P, Krausz E, Lane DP. New approaches to cancer
therapies. J Pathol. 1999 Jan;187(1):138-46. Review. |
| October 6 |
Lecture 5: Molecular Genetics of
Common Disease (Dr. Baldwin) |
*1. TBA |
| October 13 |
Lecture 6: Population Genetics (Dr.
Wyszynski) |
There are no assigned readings for this
lecture. |
| October 20 |
Lecture 7: Methods of Human Linkage
Analysis (Dr. Panhuysen) |
*1. TBA |
| October 27 |
MID-TERM
EXAM |
| November 3 |
Lecture 8: Mouse Genetics and Mouse
Models of Human Disease (Dr. Albrecht) |
*1. Silver LM. Mouse Genetics. Chapters
3 (3.2-3.3.4.2), 6(6.1-6.1.3, 6.3.1-6.5.3), 7 (7.1-7.2.2.2, 8.3.6.1-8.3.6.5),
9(9.4.1-9.4.5). This book is out of print but can be accessed online
for free at www.informatics.jax.org/silver.
*2. Human Molecular Genetics. Ch 20, pp. 575-608, Ch. 14.3.5, pp.
422-423, including Box 14.2) |
| November 10 |
Lecture 9: Fundamental Concepts in
Gene Mapping of Mendelian Diseases (Dr. Farrer) |
*1. Haines JL, Pericak-Vance MA (eds).
Approaches to Gene Mapping in Complex Human Diseases. Wiley-Liss,
New York, 1998. Chapters 1, 11, & 15.
2. Farrer LA, Bowcock AM, Hebert JM, Bonne-Tamir B, Sternlieb I,
Giagheddu M, St George-Hyslop P, Frydman M, Lossner J, Demelia L,
et al. Predictive testing for Wilson's disease using tightly linked
and flanking DNA markers. Neurology. 1991 Jul;41(7):992-9.
3. Bowcock AM, Tomfohrde J, Weissenbach J, Bonne-Tamir
B, St George-Hyslop P, Giagheddu M, Cavalli-Sforza LL, Farrer LA.
Refining the position of Wilson disease by linkage disequilibrium
with polymorphic microsatellites. Am J Hum Genet. 1994 Jan;54(1):79-87.
|
| November 17 |
Lecture 10: Identifying the Genetic
Contribution to a Trait (Dr. Wilcox) |
*1. TBA |
| November 24 |
NO LECTURE |
| December 1 |
Lecture 11: Study Designs for Gene
Identification in Complex Traits (Drs. Panhuysen and Wilcox) |
*1. TBA |
| December 8 |
Lecture 12: Confirming the Responsibility
of a Gene in Trait Etiology (Drs. Wyszynski and Albrecht) |
*1. TBA |
| December 15 |
Lecture 13: Pathways in the Natural
History of Disease (Dr. Wilcox) |
*1. TBA |
| December 22 |
FINAL EXAM |
|
|
|
|
